Evidence synthesis and scientific advisory services convert large, mixed-quality literatures into decision-ready analysis for pipelines, clinical strategy, safety, and diligence. Each assignment begins with a defined question, a documented protocol, and pre-specified search strings. Screening and data extraction follow reproducible steps so reviewers can audit inclusion, exclusion, and transformations. When appropriate, the protocol is preregistered on PROSPERO or OSF. Outputs are designed for leadership and scientific peers alike: precise briefs with options and trade-offs, method appendices with full citation sets, and figures that show effect direction and strength.
Search and selection are executed against structured sources with versioned queries and date-stamped runs. Reporting can follow PRISMA and PRISMA-S, with flow diagrams, reasons for exclusion, database and platform names, and complete strategies archived. Search strategies can undergo PRESS peer review when warranted. Quality assessment uses established tools such as RoB 2 for trials and ROBINS-I for non-randomised studies; observational work is profiled to STROBE. Signals are graded with GRADE where appropriate so decision-makers can see confidence levels and evidence gaps. Where pooling is justified, meta-analytic models are stated explicitly, heterogeneity is examined, small-study and publication-bias signals are assessed, and sensitivity checks accompany primary estimates.
Decision briefs present the question, the options, and the rationale using calibrated language. Claims are tied to the strength of evidence, sources are traceable, and uncertainty is stated when material to choices. Safety analyses use consistent coding (e.g., MedDRA), exposure ranges, and margins of safety, linked to authoritative bodies and primary data. For programme strategy, evidence lines are mapped to endpoints and estimands so clinical, regulatory, and statistical stakeholders can review on the same footing. For diligence, translational plausibility and reproducibility risks are analysed with clear flags and triggers for confirmatory work.
Operational delivery is disciplined. Draft one arrives on the scheduled date with tracked changes and a comment log explaining key decisions, assumptions, and references. One focused revision round is included to close open questions. Hand-over includes the decision brief or technical report, editable vector figures, the screened citation library (EndNote or Zotero), exportable tables (CSV/XLSX), and archived search strategies. Files integrate with document-control systems and are suitable for journal submission or internal governance as specified in the statement of work. When a living review is needed, update cadence and triggers are defined at contracting.
Ethics and data protection are treated as core requirements. Protocols, search histories, and extractions are retained for audit during the engagement and deleted on request after completion. Confidential material is handled under NDA with encrypted transfer and named-user access. Generative tools are limited to drafting assistance under strict human review; fact generation and literature decisions remain manual and documented.
Assignments are executed in English for organisations across Europe and beyond. Contracting and invoicing can be arranged in CHF, EUR, NOK, or DKK.
For scoping, provide the decision to be made, the target audience, the due date, any prior reviews or authority feedback, and required standards. A written statement of work will set the method, deliverables, schedule, and pricing as fixed or capped, with milestones aligned to internal governance.