Environmental and toxicology assessment provides decision-grade evaluations of chemicals, ingredients, formulations, and processes. Work covers exposure characterisation, hazard appraisal, and risk characterisation with explicit assumptions, uncertainty statements, and traceable sources. Deliverables are written in English for international use and support corporate affairs, regulatory filings, product stewardship, and executive decision-making.
Hazard assessment synthesises data across authoritative bodies and primary studies. Evidence from EFSA, ECHA, US EPA, IARC, WHO, and comparable sources is reviewed alongside GLP studies and peer-reviewed literature. Study quality and relevance are evaluated against OECD test guidelines and recognised appraisal tools. Weight-of-evidence judgments are linked to endpoints, species, and critical effects. Read-across, QSARs, and new approach methodologies are incorporated where appropriate, with limitations described. Key values such as NOAEL/LOAEL, BMD/BMDL, DNEL/DMEL, and reference doses or TDI/ADI are identified and justified for use in risk characterisation.
Exposure assessment defines realistic and upper-bound scenarios for consumers, workers, and the environment. Deterministic and probabilistic approaches are used as needed, with stated defaults, distributions, and data sources. Aggregate and cumulative exposure are considered where relevant. Units, absorption assumptions, and exposure frequencies are explicit. Typical tools (for example, ECETOC TRA or ConsExpo) can be applied where suitable, and PBPK modelling referenced or commissioned for specialised cases, with parameters archived for audit. Vulnerable populations and life stages are flagged, and margins of safety reflect applicable uncertainty factors.
Risk characterisation presents transparent calculations that decision-makers can trace. Margins of exposure, risk characterisation ratios, TTC frameworks, and mixture methods (concentration addition or independent action) are applied where appropriate, with reasoning tied to the strength of evidence. For mixtures and impurities, contributions are isolated where feasible and assumptions are documented. Narrative conclusions align to regulatory expectations and avoid overstated certainty. Where risk mitigation is warranted, options are presented with feasibility notes for labelling, formulation changes, or operational controls.
Regulatory alignment is maintained throughout. For EU chemicals, assessments can support REACH dossiers in IUCLID and Chemical Safety Reports, with exposure scenarios and Safety Data Sheet updates compliant with CLP/GHS. For food and nutrition, outputs map to EFSA guidance on ingredients, contaminants, and claims substantiation. For cosmetics and consumer products, safety narratives reflect SCCS and relevant regional guidance. For medical products, safety sections align to ICH language and to risk-management expectations. Region-specific variations are tracked so materials can be reused efficiently across jurisdictions.
Special topics are handled with the same discipline. Endocrine activity and disruption are considered with reference to current criteria and test batteries. Nanomaterials are described with particle size, surface characteristics, and dissolution or transformation where data permit. Environmental fate and transport are summarised with key parameters and, where needed, screening-level risk statements for compartments such as aquatic, sediment, and soil.
Operational delivery is predictable. Draft one arrives on the scheduled date with tracked changes and a comment log explaining key decisions, inputs, and references. One focused revision round is included to close open questions. Handover includes the technical memorandum or report, editable vector figures, calculation sheets, and a managed bibliography. Files integrate with document control systems and can serve as annexes to regulatory submissions or executive briefs. Confidential material is handled under NDA with encrypted transfer, named-user access, and retention limited to the period specified in the statement of work.
Assignments are executed in English for organisations across Europe and beyond. Contracting and invoicing can be arranged in CHF, EUR, NOK, or DKK.
For scoping, provide the substance or formulation, intended uses, target jurisdictions, decision questions, deadline, and any prior assessments. A written statement of work will set method, deliverables, schedule, and pricing as fixed or capped, with milestones aligned to internal governance.